I love this quote from Jan Morris's autobiography, Conundrum:
"I never did think that my own conundrum was a matter either of science or social convention. I thought it was a matter of the spirit, a kind of divine allegory, and that explanations of it were not very important anyway. What was important was the liberty of us all to live as we wished to live, to love however we wanted to love, and to know ourselves, however peculiar, disconcerting, or unclassifiable, at one with the gods and angels."
I think she really gets to the heart of our whole situation with this statement. Does it really matter whether being gay or transgendered is genetic or hormonal, or if it's just "sin?" What matters is that we live free, that we can define our own lives according to what seems most ethical and natural to us, whoever we may be. We don't live in science, we live in the mystery of our own minds, and though we live in community with connections to the people we love or live with, ultimately the only person you have to live with is yourself.
We are all alone with god.